RapamycinFungusV1, Main, Exploration, bibRecord, 000654

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

Identifieur interne : 000654 ( Main/Exploration ); précédent : 000653; suivant : 000655

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

Auteurs : Giselle Ferreira Ribeiro [Brésil] ; Caroline Gonçalves De G Es [Brésil] ; Diego Santos Onorio [Brésil] ; Cláudia Barbosa Ladeira De Campos [Brésil] ; Flavia Villaça Morais [Brésil]

Source :

PloS one [ 1932-6203 ] ; 2018.

RBID : pubmed:30138387

Descripteurs français

KwdFr :
- Adénine (analogues et dérivés), Adénine (pharmacologie), Autophagie (génétique), Blastomycose sud-américaine (génétique), Blastomycose sud-américaine (microbiologie), Mycelium (croissance et développement), Mycelium (génétique), Nutriments (génétique), Nutriments (métabolisme), Paracoccidioides (génétique), Paracoccidioides (pathogénicité), Paracoccidioides (physiologie), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (génétique), Sirolimus (pharmacologie), Stress oxydatif (effets des médicaments et des substances chimiques), Stress oxydatif (génétique).
MESH :
- analogues et dérivés : Adénine.
- croissance et développement : Mycelium.
- effets des médicaments et des substances chimiques : Stress oxydatif.
- génétique : Autophagie, Blastomycose sud-américaine, Mycelium, Nutriments, Paracoccidioides, Saccharomyces cerevisiae, Stress oxydatif.
- microbiologie : Blastomycose sud-américaine.
- métabolisme : Nutriments.
- pathogénicité : Paracoccidioides.
- pharmacologie : Adénine, Sirolimus.
- physiologie : Paracoccidioides.
- Régulation de l'expression des gènes fongiques.

English descriptors

KwdEn :
- Adenine (analogs & derivatives), Adenine (pharmacology), Autophagy (genetics), Gene Expression Regulation, Fungal (MeSH), Mycelium (genetics), Mycelium (growth & development), Nutrients (genetics), Nutrients (metabolism), Oxidative Stress (drug effects), Oxidative Stress (genetics), Paracoccidioides (genetics), Paracoccidioides (pathogenicity), Paracoccidioides (physiology), Paracoccidioidomycosis (genetics), Paracoccidioidomycosis (microbiology), Saccharomyces cerevisiae (genetics), Sirolimus (pharmacology).
MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , pharmacology : Adenine, Sirolimus.
- drug effects : Oxidative Stress.
- genetics : Autophagy, Mycelium, Nutrients, Oxidative Stress, Paracoccidioides, Paracoccidioidomycosis, Saccharomyces cerevisiae.
- growth & development : Mycelium.
- metabolism : Nutrients.
- microbiology : Paracoccidioidomycosis.
- pathogenicity : Paracoccidioides.
- physiology : Paracoccidioides.
- Gene Expression Regulation, Fungal.

Abstract

Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. The challenging environment inside the host exposes the fungus to the need of adaptation in order to circumvent nutritional, thermal, oxidative, immunological and other stresses that can directly affect their survival. Considering that autophagy is a response to abrupt environmental changes and is induced by stress conditions, this study hypothesizes that this process might be crucially involved in the adaptation of Paracoccidioides spp. to the host and, therefore, it is essential for the proper establishment of the disease. By labelling autophagous vesicles with monodansylcadaverine, autophagy was observed as an early event in cells during the normal mycelium to yeast transition, as well as in yeast cells of P. brasiliensis under glucose deprivation, and under either rapamycin or 3-methyladenine (3-MA). Findings in this study demonstrated that autophagy is triggered in P. brasiliensis during the thermal-induced mycelium to yeast transition and by glucose-limited conditions in yeasts, both of which modulated by rapamycin or 3-MA. Certainly, further genetic and in vivo analyses are needed in order to finally address the contribution of autophagy for adaptation. Yet, our data propose that autophagy possibly plays an important role in Paracoccidioides brasiliensis virulence and pathogenicity.

DOI: 10.1371/journal.pone.0202529
PubMed: 30138387
PubMed Central: PMC6107164

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000475
to stream Main, to step Curation: 000475

Le document en format XML

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<term>Adenine (pharmacology)</term>
<term>Autophagy (genetics)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Mycelium (genetics)</term>
<term>Mycelium (growth & development)</term>
<term>Nutrients (genetics)</term>
<term>Nutrients (metabolism)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Oxidative Stress (genetics)</term>
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<term>Paracoccidioides (physiology)</term>
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<term>Paracoccidioidomycosis (microbiology)</term>
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<term>Sirolimus (pharmacology)</term>
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<term>Adénine (pharmacologie)</term>
<term>Autophagie (génétique)</term>
<term>Blastomycose sud-américaine (génétique)</term>
<term>Blastomycose sud-américaine (microbiologie)</term>
<term>Mycelium (croissance et développement)</term>
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<term>Nutrients</term>
<term>Oxidative Stress</term>
<term>Paracoccidioides</term>
<term>Paracoccidioidomycosis</term>
<term>Saccharomyces cerevisiae</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autophagie</term>
<term>Blastomycose sud-américaine</term>
<term>Mycelium</term>
<term>Nutriments</term>
<term>Paracoccidioides</term>
<term>Saccharomyces cerevisiae</term>
<term>Stress oxydatif</term>
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<front><div type="abstract" xml:lang="en">Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. The challenging environment inside the host exposes the fungus to the need of adaptation in order to circumvent nutritional, thermal, oxidative, immunological and other stresses that can directly affect their survival. Considering that autophagy is a response to abrupt environmental changes and is induced by stress conditions, this study hypothesizes that this process might be crucially involved in the adaptation of Paracoccidioides spp. to the host and, therefore, it is essential for the proper establishment of the disease. By labelling autophagous vesicles with monodansylcadaverine, autophagy was observed as an early event in cells during the normal mycelium to yeast transition, as well as in yeast cells of P. brasiliensis under glucose deprivation, and under either rapamycin or 3-methyladenine (3-MA). Findings in this study demonstrated that autophagy is triggered in P. brasiliensis during the thermal-induced mycelium to yeast transition and by glucose-limited conditions in yeasts, both of which modulated by rapamycin or 3-MA. Certainly, further genetic and in vivo analyses are needed in order to finally address the contribution of autophagy for adaptation. Yet, our data propose that autophagy possibly plays an important role in Paracoccidioides brasiliensis virulence and pathogenicity.</div>
</front>
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<Abstract><AbstractText>Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. The challenging environment inside the host exposes the fungus to the need of adaptation in order to circumvent nutritional, thermal, oxidative, immunological and other stresses that can directly affect their survival. Considering that autophagy is a response to abrupt environmental changes and is induced by stress conditions, this study hypothesizes that this process might be crucially involved in the adaptation of Paracoccidioides spp. to the host and, therefore, it is essential for the proper establishment of the disease. By labelling autophagous vesicles with monodansylcadaverine, autophagy was observed as an early event in cells during the normal mycelium to yeast transition, as well as in yeast cells of P. brasiliensis under glucose deprivation, and under either rapamycin or 3-methyladenine (3-MA). Findings in this study demonstrated that autophagy is triggered in P. brasiliensis during the thermal-induced mycelium to yeast transition and by glucose-limited conditions in yeasts, both of which modulated by rapamycin or 3-MA. Certainly, further genetic and in vivo analyses are needed in order to finally address the contribution of autophagy for adaptation. Yet, our data propose that autophagy possibly plays an important role in Paracoccidioides brasiliensis virulence and pathogenicity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ribeiro</LastName>
<ForeName>Giselle Ferreira</ForeName>
<Initials>GF</Initials>
<AffiliationInfo><Affiliation>Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Góes</LastName>
<ForeName>Caroline Gonçalves de</ForeName>
<Initials>CG</Initials>
<AffiliationInfo><Affiliation>Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Onorio</LastName>
<ForeName>Diego Santos</ForeName>
<Initials>DS</Initials>
<Identifier Source="ORCID">0000-0002-1341-9789</Identifier>
<AffiliationInfo><Affiliation>Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Campos</LastName>
<ForeName>Cláudia Barbosa Ladeira de</ForeName>
<Initials>CBL</Initials>
<AffiliationInfo><Affiliation>Laboratório de Bioquímica, Biologia Celular e Molecular de Fungos, Instituto de Ciência e Tecnologia-Universidade Federal de São Paulo-UNIFESP, São José dos Campos, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morais</LastName>
<ForeName>Flavia Villaça</ForeName>
<Initials>FV</Initials>
<Identifier Source="ORCID">0000-0001-8576-9684</Identifier>
<AffiliationInfo><Affiliation>Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>08</Month>
<Day>23</Day>
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<MedlineJournalInfo><Country>United States</Country>
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<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>5142-23-4</RegistryNumber>
<NameOfSubstance UI="C025946">3-methyladenine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>JAC85A2161</RegistryNumber>
<NameOfSubstance UI="D000225">Adenine</NameOfSubstance>
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<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
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<QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
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<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025282" MajorTopicYN="N">Mycelium</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

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